CONSTRUCTION OF BHV-1 UL41 DEFECTIVE VIRUS USING THE CRISPR/CAS9 SYSTEM AND ANALYSIS OF VIRAL REPLICATION PROPERTIES

Construction of BHV-1 UL41 Defective Virus Using the CRISPR/Cas9 System and Analysis of Viral Replication Properties

Bovine herpesvirus type 1 (BHV-1) is a neurotropic herpesvirus that causes infectious rhinotracheitis and vulvovaginitis in cattle.The virion host shutoff protein encoded by the BHV-1 UL41 gene is highly conserved in the Alphaherpesvirinae subfamily.This protein can degrade viral and host messenger RNA (mRNA) to interrupt host defense and facilitat

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